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Shunt equation : ウィキペディア英語版
Shunt equation

The Shunt equation quantifies the extent that venous blood bypasses oxygenation in the capillaries of the lung.
Shunt and dead space are terms used to describe conditions where either blood flow or ventilation does not meet the other in the lung as it should for gas exchange to take place. They can also be used to describe areas or effects where blood flow and ventilation are not properly matched though both may be present to varying extents. Some refer to shunt-effect or dead space-effect to designate the ventilation/perfusion mismatch states that are less extreme than absolute shunt or dead space.
The following equation relates the percentage of blood flow that is not exposed to inhaled gas, called the shunt fraction Q_s/Q_t, to the content of oxygen in venous, arterial, and pulmonary capillary blood.
:Q_s/Q_t = (Cc_ - Ca_) / (Cc_ - Cv_) 〔Respiratory Physiology: The Essentials, J. West, 2005, 7th ed, Page 169〕
== Derivation ==
The blood entering the pulmonary system will have oxygen flux Q_t \cdot Cv_, where Cv_ is oxygen content of the venous blood and Q_t is the total cardiac output.
Similarly, the blood emerging from the pulmonary system will have oxygen flux Q_t \cdot Ca_, where Ca_ is oxygen content of the arterial blood.
This will be made up of blood that bypassed the lungs (Q_s) and that which went through the pulmonary capillaries (Q_c).
We can express this as


Q_t = Q_s + Q_c.
We can solve for Q_c:


Q_c = Q_t - Q_s.
If we add the oxygen content of Qs to Qc we get the oxygen content of Qt:
Q_t \cdot Ca_ = Q_s \cdot Cv_ + (Q_t - Q_s) \cdot Cc_
Substitute Qc as above, CcO2 is content of capillary oxygen blood.
Q_t \cdot Ca_ = Qs \cdot Cv_ + Q_t \cdot Cc_ - Qs \cdot Cc_
Multiply out the brackets.

Q_s \cdot Cc_ - Qs \cdot Cv_ = Q_t \cdot Cc_ - Qt \cdot Ca_
Get the Qs terms and the Qt terms on the same side.


Q_s \cdot (Cc_ - Cv_) = Q_t \cdot (Cc_ - Ca_)
Factor out the Q terms.



\dfrac = \dfrac } }
Divide by Qt and by (CcO2 - CvO2).

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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